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【招聘】英国医学研究理事会招聘博士后

MRC Functional Genomics Unit, University of Oxford

MRC Career Development Fellowship

Subcellular Organelles in Drosophila

We are looking for amotivated and enthusiastic post-doctoral scientist to join Dr Ji-LongLiu’s research group in the internationally renowned MRC FunctionalGenomics Unit within the University of Oxford.

The post holder will joina highly interactive research team working on subcellular organelles inDrosophila. The long-term goal is to understand the composition andregulation of subcellular organelles using Drosophila the fruitfly as amodel system. We will particularly focus on newly discoveredcytoplasmic organelles such as the U body, which contains small nuclearribonucleoproteins (snRNPs) and their assembly machinery the survivalmotor neuron (SMN) complex (Liu JL and Gall JG. PNAS. 2007 July 10;104(28):11655). SMN is the determining factor for spinal muscularatrophy (SMA), the top genetic cause of childhood mortality. Youwill develop biochemical approaches to purify U bodies and determinethe proteomics and RNAomics of the U body. Similar strategy will beapplied to study other organelles recently discovered in our group.Study of subcellular organelles by biochemical approaches promises toform a broad view on basic cellular questions, as well as shed light onmolecular mechanism of disease related to subcellular organelles.

The successful applicantshould have a strong background in biochemistry and cell biology.Experience of Drosophila genetics would be an advantage, althoughtraining will be given. Excellent organisational and communicationskills will be required, together with the ability to work well withina team.

You will work in the MRCUnit within the Department of Physiology, Anatomy and Genetics at theUniversity of Oxford. Oxford has an active Drosophila community and theOxford Fly Club meet monthly to discuss their newest findings onfruitflies. The Functional Genomics Unit is a world-renowned centre forcomparative genomics and research into neurological disorders usingmodel organisms. Additional information about the Unit can be found atwww.mrcfgu.ox.ac.uk, whilst informal enquiries can be made to DrJi-Long Liu at jilong.liu@dpag.ox.ac.uk. For further information aboutthe MRC please visit www.mrc.ac.uk.

This post is availablefrom October 2010. This is a 3 year training and development positionfor a post-doctoral scientist. It provides opportunities to developresearch project skills and develop collaborative links with colleagueswithin the University of Oxford and elsewhere. Starting salary will bein the range £26,022 to £28,178 pa. You will be entitled to benefitsincluding 30 days annual leave, an excellent pension scheme and accessto MRC training.

Applications for this role must be made online at http://jobs.mrc.ac.uk.If you do not have internet access or experience technicaldifficulties, please call 01793 301156, quoting reference numberFGU10/200.

If you would like toreceive this advert in large print, Braille, audio, or electronicformat/ hard copy, please contact the Recruitment team at the MRCShared Service Centre on the telephone number above or email recruitment@ssc.mrc.ac.uk.

The MRC is an Equal Opportunities Employer.

Closing date: 24 May 2010. Interviews to be held: 22 June 2010.

The MRC is an Equal Opportunities Employer.

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